It is apt that the U.S. House of Representatives recently formally recognized the Armenian genocide and called for “education” about the United States’ own humanitarian response. Just over 120 years ago, the House passed a different resolution regarding the Armenians that confirmed a fundamental departure in U.S. foreign policy. That event signaled that the United States was becoming a great power with global responsibilities and would no longer remain indifferent to events beyond its continent. The House’s latest action could serve as another watershed moment in American diplomacy if it challenges a new isolationist spirit and stimulates a fresh debate over the nation’s international role.