Diclofenac Sodium: (Martindale: The Complete Drug Reference) Drug Nomenclature

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Diclofenac Sodium (Martindale: The Complete Drug Reference)
Drug Nomenclature
Chemical Name: Sodium [2-(2,6-dichloroanilino)phenyl]acetate
Form and Weight: C14H10Cl2NNaO2= 318.1
CAS: 15307-79-6
Note: DICL is a code approved by the BP 2020 for use on single unit doses of eye drops containing diclofenac sodium where the individual
container may be too small to bear all the appropriate labelling information.
Pharmacopoeias: In Chin. , Eur. (see Refer to ), Jpn , US , and Viet.Ph. Eur. 9 ( Diclofenac Sodium ). A white to slightly yellowish, slightly
hygroscopic, crystalline powder. Sparingly soluble in water; soluble in alcohol; slightly soluble in acetone; freely soluble in methyl alcohol.
Store in airtight containers. Protect from light.USP 43 ( Diclofenac Sodium ). A white to off-white, hygroscopic, crystalline powder. Sparingly
soluble in water; soluble in alcohol; practically insoluble in chloroform and in ether; freely soluble in methyl alcohol. pH of a 1% solution in
water is between 7.0 and 8.5. Store in airtight containers. Protect from light.
Edit Dates: 15-Sep-1997; 15-Jul-1998; 09-Mar-2000; 06-Nov-2001; 20-Aug-2003; 31-May-2006; 22-Nov-2007; 10-Sep-2008; 20-Aug-2010; 08-Jan-
2014; 22-Mar-2021
Synonyms
Diclofenac-Natrium; Diclofenaco sódico; Diclofenacum natricum; Diclofénac sodique; Diclophenac Sodium; Diklofenaakkinatrium; Diklofenak
sodná sůl; Diklofenak Sodyum; Diklofenaknatrium; Diklofenako natrio druska; Diklofenák-nátrium; GP-45840; Δικλοφαινάκη νατριούχος; ジクロ
フェナクナトリウム
United States Adopted Names

Diclofenac Sodium
British Approved Names

Diclofenac Sodium [BANM]
International Nonproprietary Names

Diclofenac Sodium [rINNM (en)]
Diclofenaco sódico [rINNM (es)]
Diclofénac Sodique [rINNM (fr)]
Natrii Diclofenacum [rINNM (la)]
Натрий Диклофенак [rINNM (ru)]
Anatomic Therapeutic Chemical Classification

D11AX18
ATC Code (veterinary)

QD11AX18
Uses and Administration

Diclofenac, a phenylacetic acid derivative, is an NSAID ( Refer to ). It is used mainly as the sodium salt for the relief of pain and inflammation
in various conditions: musculoskeletal and joint disorders such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis; peri-
articular disorders such as bursitis and tendinitis; soft-tissue disorders such as sprains and strains; and other painful conditions such as renal
colic, acute gout, dysmenorrhoea, migraine, and after some surgical procedures. It has also been used in some countries for the
management of actinic keratoses and fever. Eye drops of diclofenac sodium are used for the prevention of intra-operative miosis during
cataract extraction, for the treatment of inflammation after surgery or laser treatment of the eye, for pain in corneal epithelial defects after
surgery or accidental trauma, and for the relief of ocular signs and symptoms of seasonal allergic conjunctivitis.
The usual oral or rectaldose of diclofenac sodium is 75 to 150 mg daily in divided doses. In the UK the maximum dose regardless of route or
indication is 150 mg daily; however, in the USA a maximum oral dose of 200 mg daily is allowed in the treatment of rheumatoid arthritis.
Modified-release preparations of diclofenac sodium are available for oral use. Diclofenac has also been given in equivalent oral doses as the
free acid in dispersible preparations for short-term treatment up to 3 months long. Diclofenac is also given orally as the potassium salt.
Doses of the potassium salt are similar to those for diclofenac sodium. Diclofenac potassium is also used in the treatment of migraine in an
initial dose of 50 mg taken at the first signs of an attack; an additional dose of 50 mg may be taken after 2 hours if symptoms persist. If
necessary further doses of 50 mg may be taken every 4 to 6 hours to a maximum daily dose of 200 mg.
Diclofenac sodium may also be given by deep intramuscular injection into the gluteal muscle in a dose of 75 mg once daily or, if required in
severe conditions, 75 mg twice daily. Diclofenac sodium may also be given as a continuous or intermittent intravenous infusion in glucose 5%
or sodium chloride 0.9% (both previously buffered with sodium bicarbonate) or as a bolus intravenous injection. For the treatment of
postoperative pain a dose of 75 mg may be given over 30 to 120 minutes or as a bolus injection. The dose may be repeated once after 4 to 6
hours if necessary. To prevent postoperative pain, an initial dose of 25 to 50 mg diclofenac sodium may be given after surgery over 15 to 60
minutes followed by 5 mg/hour to a maximum of 150 mg daily. Alternatively, the initial dose may be given as a bolus injection over 5 to 60
seconds followed by additional injections up to the maximum daily dosage; this may be repeated after 4 to 6 hours if necessary although the
total dose should not exceed the maximum daily dose of 150 mg. The maximum period recommended for parenteral use is 2 days.
Diclofenac sodium is also used intramuscularly in renal colic in a dose of 75 mg repeated once after 30 minutes if necessary.
For dosage details in children, see Refer to .
Diclofenac sodium is used as a 0.1% ophthalmic solution in various situations:
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for the prevention of intra-operative miosis during cataract surgery, it is instilled in the appropriate eye 4 times during the 2 hours before
surgery
for the treatment of postoperative inflammation after cataract surgery, it is instilled 4 times daily for up to 28 days starting 24 hours after
surgery
for the control of post-photorefractive keratectomy pain, it is instilled twice in the hour before surgery, then one drop twice at 5-minute
intervals immediately after the procedure, and then every 2 to 5 hours while awake for up to 24 hours
for pain control after accidental trauma, one drop is instilled 4 times daily for up to 2 days
in the treatment of inflammation and discomfort after strabismus surgery, one drop is instilled 4 times daily for the first week; this is reduced
to 3 times daily in the second week, twice daily in the third week, and as required for the fourth week
for the control of inflammation after argon laser trabeculoplasty, one drop is instilled 4 times during the 2 hours before the procedure
followed by one drop 4 times daily for up to 7 days after the procedure
for the treatment of pain and discomfort after radial keratotomy, one drop is instilled before surgery followed by one drop immediately after
surgery and then one drop 4 times daily for up to 2 days
to relieve symptoms of seasonal allergic conjunctivitis, one drop is instilled 4 times daily as necessary
Diclofenac diethylamine is used topicallyas a gel containing the equivalent of 1% of diclofenac sodium for the local symptomatic relief of pain
and inflammation; it is applied to the affected site 3 or 4 times daily; treatment should be reviewed after 14 days or after 28 days if used for
osteoarthritis. A topical spray containing diclofenac sodium 4% is also available; 4 or 5 sprays (32 or 40 mg of diclofenac sodium) may be
applied 3 times daily, up to a maximum of 15 sprays (120 mg of diclofenac sodium) daily; treatment should be reviewed after 7 or 8 days. A
topical solution of diclofenac sodium 1.6% is available for the treatment of osteoarthritis in superficial joints such as the wrist or knee; it is
applied in small aliquots to achieve a total of 20 or 40 drops, depending on the size of the joint, and repeated four times daily. Diclofenac is
also used in the management of actinic keratoses; it is applied twice daily as diclofenac sodium gel 3% for 60 to 90 days but the optimum
therapeutic effect may not be seen until 30 days after the end of treatment. Diclofenac epolamine is also used topically as a plaster
containing the equivalent of 1% of diclofenac sodium for local symptomatic pain relief in ankle sprain and epicondylitis. In the treatment of
ankle sprain, 1 plaster is applied once daily for a maximum of 3 days and for epicondylitis, 1 plaster is applied twice daily for a maximum of
14 days.
Diclofenac is available as a combination preparation with misoprostol (Refer to) for patients at risk of NSAID-induced peptic ulceration.
(last reviewed 2014-01-08; last modified 2010-06-02)
Administration
In Children
In children aged 1 to 12 years the licensed UKoral or rectal dose of diclofenac sodium for juvenile idiopathic arthritis is 1 to 3 mg/kg daily in
divided doses. In children aged 6 to 12 years diclofenac sodium may also be given rectally for the treatment of acute postoperative pain,
either alone or as an adjunct to opiate therapy; a usual dose is 1 to 2 mg/kg daily in divided doses for a maximum of 4 days. The parenteral
route is not licensed for use in children although it has been used (see below).
The BNFC suggests slightly different doses of diclofenac sodium: in the management of rheumatic disease, including juvenile idiopathic
arthritis, in children from 6 months to 17 years of age, it recommends an oral dose of 3 to 5 mg/kg daily, in 2 or 3 divided doses. For relief of
mild to moderate pain and inflammation in, for example, soft-tissue disorders, the recommended oral or rectal dose in children from 6
months to 17 years of age is 0.3 to 1 mg/kg (maximum 50 mg) given three times daily; children 2 to 17 years of age may be given a similar
dose once or twice daily by intravenous infusionor deep intramuscular (gluteal) injection for up to 2 days for postoperative pain. Rectal doses
may also be given for postoperative pain to children from 6 months to 17 years of age, according to body-weight, for a maximum of 4 days:
those weighing 8 to 11 kg may be given 12.5 mg twice daily and heavier children 1 mg/kg three times daily.
Regardless of route or indication, a maximum daily dose of 150 mg should not be exceeded.
Diclofenac potassium has also been used in children aged over 14 years for the treatment of rheumatic disease, musculoskeletal disorders,
and postoperative pain; it is given in an oral dose of 75 to 100 mg daily in 2 or 3 divided doses.
Topical
References to the use of plasters providing sustained topical release of diclofenac epolamine,1-6and reviews of the use of a topical solution of
diclofenac with dimethyl sulfoxide to treat osteoarthritis.7,8 The latter was found to be effective and better tolerated than oral use.
References
1. Galeazzi M, Marcolongo R. A placebo-controlled study of the efficacy and tolerability of a nonsteroidal anti-inflammatory drug, DHEP
plaster, in inflammatory peri-and extra-articular rheumatological diseases.Drugs Exp Clin Res. 1993; 19: 107–15. PubMed
2. Dreiser RL, Tisne-Camus M. DHEP plasters as a topical treatment of knee osteoarthritis—a double-blind placebo-controlled study.Drugs
Exp Clin Res. 1993; 19: 117–23. PubMed
3. Affaitati G, et al.. Effects of topical diclofenac (DHEP plaster) on skin, subcutis and muscle pain thresholds in subjects without spontaneous
pain.Drugs Exp Clin Res. 2001; 27: 69–76. PubMed
4. Jenoure P-J. Évaluation d'un anti-inflammatoire non stéroïdien topique dans le traitement de la douleur et de l'inflammation: exemple de
Flector Tissugel® 1% dispositif local bioadhésif de diclofénac épolamine.Presse Med. 2004; 33: 10–13. PubMed
5. Brühlmann P, et al.. Short-term treatment with topical diclofenac epolamine plaster in patients with symptomatic knee osteoarthritis:
pooled analysis of two randomised clinical studies.Curr Med Res Opin. 2006; 22: 2429–38. PubMed
6. Alessandri F, et al.. Topical diclofenac patch for postoperative wound pain in laparoscopic gynecologic surgery: a randomized study.J Minim
Invasive Gynecol. 2006; 13: 195–200. PubMed
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7. Towheed TE. Pennsaid therapy for osteoarthritis of the knee: a systematic review and metaanalysis of randomized controlled trials.J
Rheumatol. 2006; 33: 567–73. PubMed
8. Moen MD. Topical diclofenac solution.Drugs. 2009; 69: 2621–32. PubMed
Actinic keratoses
Diclofenac sodium 3% in hyaluronic acid gel is used1-3 in the treatment of actinic keratoses (see Basal Cell and Squamous Cell Carcinoma,
Refer to ), and a meta-analysis4 found it to be of benefit, despite previous concerns that the preparation may not be significantly more
effective than hyaluronic acid gel alone.5An open-label comparison involving 30 patients with multiple actinic keratoses suggested that 90
days of treatment with diclofenac sodium 3% gel (to lesions on one side of the face and scalp) was better tolerated, but slightly less effective,
than 28 days of treatment with fluorouracil 5% cream (to lesions on the other side).6
References
1. Rivers JK, McLean DI. An open study to assess the efficacy and safety of topical 3% diclofenac in a 2.5% hyaluronic acid gel for the
treatment of actinic keratoses.Arch Dermatol. 1997; 133: 1239–42. PubMed
2. Rivers JK, et al.. Topical treatment of actinic keratoses with 3.0% diclofenac in 2.5% hyaluronan gel.Br J Dermatol. 2002; 146: 94–100.
PubMed
3. Ulrich C, et al.. Treatment of multiple actinic keratoses with topical diclofenac 3% gel in organ transplant recipients: a series of six cases.Br J
Dermatol. 2007; 156 40–2. PubMed
4. Pirard D. et al. Three percent diclofenac in 2.5% hyaluronan gel in the treatment of actinic keratoses: a meta-analysis of the recent
studies.Arch Dermatol Res. 2005; 297: 185–9. PubMed
5. McEwan LE, Smith JG. Topical diclofenac/hyaluronic acid gel in the treatment of solar keratoses.Australas J Dermatol. 1997; 38: 187–9.
PubMed
6. Smith SR, et al.. Bilateral comparison of the efficacy and tolerability of 3% diclofenac sodium gel and 5% 5-fluorouracil cream in the
treatment of actinic keratoses of the face and scalp.J Drugs Dermatol. 2006; 5: 156–9. PubMed
Pain
Reviews.
References
1. McCormack PL, Scott LJ. Diclofenac sodium injection (Dyloject®): in postoperative pain.Drugs ibid.. 2008; 68: 123–30. PubMed
2. Derry P, et al.. Single dose oral diclofenac for acute postoperative pain in adults. Available in The Cochrane Database of Systematic
Reviews; Issue 2. Chichester: John Wiley; 2009 (accessed 09/09/09). PubMed
3. Standing JF, et al.. Diclofenac for acute pain in children. Available in The Cochrane Database of Systematic Reviews; Issue 4. Chichester:
John Wiley; 2009 (accessed 18/03/10). PubMed
Precautions
As for NSAIDs in general, Refer to .
Systemic diclofenac is contra-indicated in patients with moderate to severe heart failure (NYHA class II to IV), ischaemic heart disease,
peripheral arterial disease, or cerebrovascular disease. It should be used with caution in patients with significant risk factors for
cardiovascular events such as hypertension, hyperlipidaemia, diabetes mellitus, and smoking. Systemic diclofenac is also contra-indicated in
patients with severe hepatic or renal impairment.
In addition, use of intravenous diclofenac is contra-indicated in patients with moderate or severe renal impairment, hypovolaemia, or
dehydration; it should also not be given intravenously to patients with a history of haemorrhagic diathesis, cerebrovascular bleeding
(including suspected), or asthma nor in patients undergoing surgery with a high risk of haemorrhage.
Ophthalmic preparations containing diclofenac should not be used by patients who wear soft contact lenses.
Breast feeding
Diclofenac is distributed into breast milk although the BNF considers the amount to be too small to be harmful to breast-fed infants.
Porphyria
The Drug Database for Acute Porphyria, compiled by the Norwegian Porphyria Centre (NAPOS) and the Porphyria Centre Sweden, classifies
diclofenac as probably porphyrinogenic; it should be prescribed only for compelling reasons and precautions should be considered in all
patients.1
References
1. The Drug Database for Acute Porphyria. Available at: Link (accessed 23/10/11)
Veterinary use
Veterinary use of diclofenac in cattle in South Asia has been associated with severe decline in the numbers of vultures, to whom the residues
are highly toxic if they consume the carcasses.1,2 Meloxicam (Refer to) has been suggested as an alternative.
References
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1. Shultz S, et al.. Diclofenac poisoning is widespread in declining vulture populations across the Indian subcontinent.Proc Biol Sci. 2004; 271
458–S460. PubMed
2. Sharp D. Meloxicam to prevent rabies?Lancet. 2006; 367: 887–8. PubMed
Adverse Effects, Treatment and Precautions

Adverse Effects and Treatment
As for NSAIDs in general, Refer to .
There may be pain and, occasionally, tissue damage at the site of injection when diclofenac is given intramuscularly. Diclofenac suppositories
can cause local irritation. Transient burning and stinging may occur with diclofenac ophthalmic solution; more serious corneal adverse
effects have also occurred (see Effects on the Eyes, Refer to ). Topical preparations of diclofenac, such as plasters and gel, may cause
application site reactions.
Incidence of adverse effects
A review of worldwide clinical studies with diclofenac1 has reported the incidence of drug-associated adverse effects to be about 12%; about
16% of patients who had adverse effects stopped treatment (a figure corresponding to about 2% of the entire patient sample). The most
frequently reported adverse effects were gastrointestinal and were reported in 7.6% of patients. CNS-related adverse effects were reported
in 0.7% of patients and allergy or local reactions in 0.4%. This and other reviews2 have shown that adverse effects associated with diclofenac
are usually mild and transient and appear to be unrelated to the dose given.
The incidence of adverse effects in children is similar to that in adults.3
References
1. Willkens RF. Worldwide clinical safety experience with diclofenac.Semin Arthritis Rheum. 1985; 15 105–10. PubMed
2. Small RE. Diclofenac sodium.Clin Pharm. 1989; 8: 545–8. PubMed
3. Standing JF, et al.. Prospective observational study of adverse drug reactions to diclofenac in children.Br J Clin Pharmacol. 2009; 68: 243–51.
PubMed
Effects on the blood
Results of a large survey undertaken to assess the relation between agranulocytosis, aplastic anaemia, and drug exposure indicated that
diclofenac was significantly associated with aplastic anaemia, providing an estimated tenfold increase in risk.1 There are reports of other
haematological abnormalities including haemolytic anaemia,2,3thrombocytopenia,4,5 neutropenia,5and agranulocytosis6 occurring in patients
given diclofenac.
Localised spontaneous bleeding,7bruising,8 inhibition of platelet aggregation,7 and prolonged bleeding time8 have been reported.
References
1. The International Agranulocytosis and Aplastic Anemia Study. Risks of agranulocytosis and aplastic anemia: a first report of their relation
to drug use with special reference to analgesics.JAMA. 1986; 256: 1749–57. PubMed
2. López A, et al.. Autoimmune hemolytic anemia induced by diclofenac.Ann Pharmacother. 1995; 29: 787. PubMed
3. Ahrens N, et al.. Misdiagnosis in patients with diclofenac-induced hemolysis: new cases and a concise review.Am J Hematol. 2006; 81: 128–
31. PubMed
4. George S, Rahi AHS. Thrombocytopenia associated with diclofenac therapy.Am J Health-Syst Pharm. 1995; 52: 420–1. PubMed
5. Kim HL, Kovacs MJ. Diclofenac-associated thrombocytopenia and neutropenia.Ann Pharmacother. 1995; 29: 713–15. PubMed
6. Colomina P, Garcia S. Agranulocytosis caused by diclofenac.DICP Ann Pharmacother. 1989; 23: 507. PubMed
7. Price AJ, Obeid D. Spontaneous non-gastrointestinal bleeding associated with diclofenac.Lancet. 1989; ii: 1520. PubMed
8. Khazan U, et al.. Diclofenac sodium and bruising.Ann Intern Med. 1990; 112: 472–3. PubMed
Effects on the cardiovascular system
For a discussion of the cardiovascular effects of NSAIDs, including diclofenac, see Refer to .
Effects on electrolytes
A syndrome resembling the syndrome of inappropriate antidiuretic hormone secretion has been reported in elderly women given
diclofenac.1,2Also the UK CSM had received a report of fatal hyponatraemia in another elderly woman.2
References
1. Petersson I, et al.. Water intoxication associated with non-steroidal anti-inflammatory drug therapy.Acta Med Scand. 1987; 221: 221–3.
PubMed
2. Cheung NT, et al.. Syndrome of inappropriate secretion of antidiuretic hormone induced by diclofenac.BMJ. 1993; 306: 186. PubMed
Effects on the eyes
A patient who had been taking oral diclofenac for several years and had increasingly complained of dry, gritty eyes noticed that eye irritation
disappeared within 3 days when diclofenac had to be stopped because of gastrointestinal effects.1
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Ocular diclofenac and related drugs have been implicated in reports of corneal toxicity. Ulceration of the conjunctiva or cornea, corneal or
scleral melts, and perforations have been reported in patients using diclofenac eye drops, particularly after cataract surgery.2-5Keratitis and
perforations were also reported with ketorolac eye drops,4 although less frequently. For mention of corneal melting with bromfenac, see
Refer to .
References
1. Reid ALA, Henderson R. Diclofenac and dry, irritable eyes.Med J Aust. 1994; 160: 308. PubMed
2. Lin JC, et al.. Corneal melting associated with use of topical nonsteroidal anti-inflammatory drugs after ocular surgery.Arch Ophthalmol.
2000; 118: 1129–32. PubMed
3. Congdon NG, et al.. Corneal complications associated with topical ophthalmic use of nonsteroidal antiinflammatory drugs.J Cataract
Refract Surg. 2001; 27: 622–31. PubMed
4. Guidera AC, et al.. Keratitis, ulceration, and perforation associated with topical nonsteroidal anti-inflammatory drugs.Ophthalmology. 2001;
108: 936–44. PubMed
5. Flach AJ. Corneal melts associated with topically applied nonsteroidal anti-inflammatory drugs.Trans Am Ophthalmol Soc. 2001; 99: 205–10.
PubMed
Effects on the gastrointestinal tract
The most frequent adverse effects reported in patients given diclofenac systemically are gastrointestinal in nature. Typical reactions include
epigastric pain, nausea, vomiting, and diarrhoea. Rarely peptic ulcer and gastrointestinal bleeding have occurred. Diclofenac has also been
implicated as the causative agent in colonic ulceration,1 small bowel perforation,2 and pseudomembranous colitis.3Diclofenac suppositories
may cause local reactions such as itching, burning, or exacerbation of haemorrhoids.
References
1. Carson J, et al.. Colonic ulceration and bleeding during diclofenac therapy.N Engl J Med. 1990; 323: 135. PubMed
2. Deakin M, et al.. Small bowel perforation associated with an excessive dose of slow release diclofenac sodium.BMJ. 1988; 297: 488–9.
PubMed
3. Gentric A, Pennec YL. Diclofenac-induced pseudomembranous colitis.Lancet. 1992; 340: 126–7. PubMed
Effects on the kidneys
Renal papillary necrosis1 and nephrotic syndrome2-4 have been reported in patients taking diclofenac. See also Effects on Electrolytes, Refer
to .
References
1. Scott SJ, et al. Renal papillary necrosis associated with diclofenac sodium.BMJ. 1986; 292: 1050.
2. Beun GDM, et al.. Isolated minimal change nephropathy associated with diclofenac.BMJ. 1987; 295: 182–3. PubMed
3. Yinnon AM, et al.. Nephrotic syndrome associated with diclofenac sodium.BMJ. 1987; 295: 556.
4. Tattersall J, et al.. Membranous nephropathy associated with diclofenac.Postgrad Med J. 1992; 68: 392–3. PubMed
Effects on the liver
Elevations of serum aminotransferase activity and clinical hepatitis,1-8 including fatal fulminant hepatitis2,5 have occurred in patients taking
diclofenac. There has also been a case report of hepatorenal damage attributed to diclofenac.9 Analysis10 of 180 of the cases of diclofenac-
associated hepatic injury received by the FDA between November 1988 and June 1991 suggested an increased risk of hepatotoxicity in female
patients and those taking diclofenac for osteoarthritis. Hepatotoxicity had been detected within 6 months of starting diclofenac in 85% of the
patients. The biochemical pattern of injury was hepatocellular or mixed hepatocellular in 66% of patients and cholestatic injury was found in
8% of patients. Signs of hypersensitivity were uncommon and it was considered that the mechanism of hepatic injury was likely to be a
metabolic idiosyncratic reaction rather than due to intrinsic toxicity of diclofenac.
References
1. Dunk AA, et al.. Diclofenac hepatitis.BMJ. 1982; 284: 1605–6. PubMed
2. Breen EG, et al.. Fatal hepatitis associated with diclofenac.Gut. 1986; 27: 1390–3. PubMed
3. Schapira D, et al.. Diclofenac-induced hepatotoxicity.Postgrad Med J. 1986; 62: 63–5. PubMed
4. Ryley NG, et al.. Diclofenac associated hepatitis.Gut. 1989; 30: 708.
5. Helfgott SM, et al.. Diclofenac-associated hepatotoxicity.JAMA. 1990; 264: 2660–2. PubMed
6. Purcell P, et al.. Diclofenac hepatitis.Gut. 1991; 32: 1381–5. PubMed
7. Bhogaraju A, et al.. Diclofenac-associated hepatitis.South Med J. 1999; 92: 711–13. PubMed
8. Greaves RRSH, et al.. Inadvertent diclofenac rechallenge from generic and non-generic prescribing, leading to liver transplantation for
fulminant liver failure.Eur J Gastroenterol Hepatol. 2001; 13: 71–3. PubMed
9. Diggory P, et al.. Renal and hepatic impairment in association with diclofenac administration.Postgrad Med J. 1989; 64: 507–8. PubMed
10. Banks AT, et al.. Diclofenac-associated hepatotoxicity: analysis of 180 cases reported to the Food and Drug Administration as adverse
reactions.Hepatology. 1995; 22: 820–7. PubMed
Effects on the skin
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Self-limiting skin reactions such as rash or pruritus may occur in patients given diclofenac. More serious skin reactions attributed to
diclofenac include bullous dermatitis1 and erythema multiforme.2,3 Local irritation and necrosis have occurred on intramuscular injection of
diclofenac.4-7
References
1. Gabrielsen TØ, et al. Drug-induced bullous dermatosis with linear IgA deposits along the basement membrane.Acta Derm Venereol
(Stockh). 1981; 61: 439–41. PubMed
2. Morris BAP, Remtulla SS. Erythema multiforme major following use of diclofenac.Can Med Assoc J. 1985; 133: 665. PubMed
3. Young J. Erythema multiforme-like eruption as a result of 'Solaraze' treatment.J Dermatol Treat. 2003; 14: 189. PubMed
4. Stricker BHC, van Kasteren BJ. Diclofenac-induced isolated myonecrosis and the Nicolau syndrome.Ann Intern Med. 1992; 117: 1058.
PubMed
5. Pillans PI, O'Connor N. Tissue necrosis and necrotising fasciitis after intramuscular administration of diclofenac.Ann Pharmacother. 1995;
29: 264–6. PubMed
6. Ezzedine K, et al.. Nicolau syndrome following diclofenac administration.Br J Dermatol. 2004; 150: 385–7. PubMed
7. Mutalik S, Belgaumkar V. Nicolau syndrome: a report of 2 cases.J Drugs Dermatol. 2006; 5: 377–8. PubMed
Hypersensitivity
Aspirin-sensitive asthmatic patients have developed reactions (rhinorrhoea, tightness of chest, wheezing, dyspnoea) when challenged with
diclofenac in doses of 10 to 25 mg1 and the UK CSM has received a report of an aspirin-sensitive patient who died from acute asthma 4 hours
after a single 25-mg dose of diclofenac.2
Anaphylactic shock has been reported.3
References
1. Szczeklik A, et al. Asthmatic attacks induced in aspirin-sensitive patients by diclofenac and naproxen.BMJ. 1977; 2: 231–2. PubMed
2. CSM/MCA. Avoid all NSAIDs in aspirin-sensitive patients.Current Problems. 1993; 19: 8. online
3. Dux S, et al.. Anaphylactic shock induced by diclofenac.BMJ. 1983; 286: 1861. PubMed
Interactions
For interactions associated with NSAIDs, see Refer to .
Diclofenac should not be given intravenously to patients already receiving other NSAIDs or anticoagulants including low-dose heparin.
Ciclosporin
Deterioration in renal function has been attributed to the use of diclofenac with ciclosporin.1 Increased concentrations of diclofenac were
also noted with ciclosporin;2licensed product information for ciclosporin recommends that the dosage of diclofenac should be reduced by
about one-half when the two are given together.
References
1. Branthwaite JP, Nicholls A. Cyclosporin and diclofenac interaction in rheumatoid arthritis.Lancet. 1991; 337: 252. PubMed
2. Kovarik JM, et al.. Cyclosporine and nonsteroidal antiinflammatory drugs: exploring potential drug interactions and their implications for
the treatment of rheumatoid arthritis.J Clin Pharmacol. 1997; 37: 336–43. PubMed
Corticosteroids
Concomitant use of ophthalmic preparations containing diclofenac with those containing corticosteroids in patients with significant pre-
existing corneal inflammation may increase the risk of developing corneal complications.
Diuretics
Deterioration in renal function has been attributed to the use of diclofenac withtriamterene.1
References
1. Härkönen M, Ekblom-Kullberg S. Reversible deterioration of renal function after diclofenac in patient receiving triamterene.BMJ. 1986; 293:
698–9.
Gastrointestinal drugs
A decrease in the plasma concentration of diclofenac has been reported1 when given after sucralfate.
References
1. Pedrazzoli J, et al.. Short-term sucralfate administration alters potassium diclofenac absorption in healthy male volunteers.Br J Clin
Pharmacol. 1997; 43: 104–8. PubMed
Lipid regulating drugs
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Colestyramine appears substantially to reduce the bioavailability of diclofenac when the two drugs are given together;1colestipol produces a
similar but smaller effect.
References
1. al-Balla SR, et al.. The effects of cholestyramine and colestipol on the absorption of diclofenac in man.Int J Clin Pharmacol Ther. 1994; 32:
441–5. PubMed
Misoprostol
The plasma concentration of diclofenac was reduced when it was given as a 100-mg dose daily in the form of a modified-release preparation
to subjects receiving misoprostol 800 micrograms daily.1Use together was also associated with an increase in the incidence and severity of
gastrointestinal effects. Studies by the manufacturer2 had failed to find any significant pharmacokinetic interactions between diclofenac and
misoprostol when given in a formulation containing diclofenac 50 mg and misoprostol 200 micrograms.
References
1. Dammann HG, et al.. Differential effects of misoprostol and ranitidine on the pharmacokinetics of diclofenac and gastrointestinal
symptoms.Br J Clin Pharmacol. 1993; 36: 345–9.
2. Karim A. Pharmacokinetics of diclofenac and misoprostol when administered alone or as a combination product.Drugs. 1993; 45 7–14.
PubMed
Parasympathomimetics
Licensed product information for acetylcholine chloride ophthalmic preparations has stated that there have been reports thatacetylcholine
and carbacholhave been ineffective when used in patients treated with topical (ophthalmic) NSAIDs.
Pharmacokinetics
Diclofenac is rapidly absorbed when given as an oral solution, sugar-coated tablets, rectal suppository, or by intramuscular injection. It is
absorbed more slowly when given as enteric-coated tablets, especially when this dosage form is given with food. Although diclofenac given
orally is almost completely absorbed, it is subject to first-pass metabolism so that about 50% of the drug reaches the systemic circulation in
the unchanged form. Diclofenac is also absorbed percutaneously. At therapeutic concentrations it is more than 99% bound to plasma
proteins. Diclofenac penetrates synovial fluid where concentrations may persist even when plasma concentrations fall; small amounts are
distributed into breast milk. The terminal plasma half-life is about 1 to 2 hours. Diclofenac is metabolised to 4′- hydroxydiclofenac , 5-
hydroxydiclofenac, 3′-hydroxydiclofenac, and 4′,5-dihydroxydiclofenac. It is then excreted in the form of glucuronide and sulfate conjugates,
mainly in the urine (about 60%) but also in the bile (about 35%); less than 1% is excreted as unchanged diclofenac.
References.
References
1. Fowler PD, et al.. Plasma and synovial fluid concentrations of diclofenac sodium and its major hydroxylated metabolites during long-term
treatment of rheumatoid arthritis.Eur J Clin Pharmacol. 1983; 25: 389–94. PubMed
2. Maggi CA, et al.. Comparative bioavailability of diclofenac hydroxyethylpyrrolidine vs diclofenac sodium in man.Eur J Clin Pharmacol. 1990;
38: 207–8. PubMed
3. Davies NM, Anderson KE. Clinical pharmacokinetics of diclofenac: therapeutic insights and pitfalls.Clin Pharmacokinet. 1997; 33: 184–213.
PubMed
4. Brenner SS, et al.. Influence of age and cytochrome P450 2C9 genotype on the steady-state disposition of diclofenac and celecoxib.Clin
Pharmacokinet. 2003; 42: 283–92. PubMed
5. Hinz B, et al.. Bioavailability of diclofenac potassium at low doses.Br J Clin Pharmacol. 2005; 59: 80–4. PubMed
6. Standing JF, et al.. Population pharmacokinetics of oral diclofenac for acute pain in children.Br J Clin Pharmacol. 2008; 66: 846–53. PubMed
7. Miyatake S, et al.. Randomized clinical comparisons of diclofenac concentration in the soft tissues and blood plasma between topical and
oral applications.Br J Clin Pharmacol. 2009; 67: 125–9. PubMed
Preparations: Single-Ingredient
The following preparations list represents a compilation of all available salt forms or related substances for this drug product.
The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.
ARGENTINA: Acloxigenac; Ainedif¤; Aktiosan¤; Aldoron NF¤; Algicler; Algioxib; Anaflex; Artrostop T; Artrostop; ATM 101¤; Atomo
Desinflamante Geldic; Banoclus; Befol; Blokium Prost¤; Blokium Protect; Blokium; Calmoflex; Cataflam¤; Curinflam VL¤; Curinflam; Damixa¤;
Desinflam¤; DFN¤; Diastone; Diclac; Diclodol¤; Diclofilab¤; Diclogesic; Diclogrand; Diclolabsa; Diclolam; Diclomar; Diclonex; Diclonovag;
Dicloreumol¤; Diclovann K; Difenac Forte; Difenac; Dilam¤; Dioxaflex Migra; Dioxaflex Protect; Dioxaflex; Disipan; Distec¤; Dolo Tomanil¤;
Dolofenac; Doloneitor¤; Dolvan; Doxtran¤; Excelentia Analgesico¤; Faboflem¤; Flexin¤; Flexiplen Plus; Flexiplen; Flogenac¤; Flogolisin;
Flotac¤; Fluxpiren¤; Gel Antiinflamatorio; Gentisalyl; Ibuxim Diclo; Iglodine; Imanol¤; Ingeclof¤; Kamox¤; Kinalgin; Klonafenac; Lafenac;
Lenitil¤; Levedad; Lorbifenac¤; Metaflex; Miocalm¤; Nalgiflex; Natura Fenac; Norviken; Oxa; Oxaprost; Pronix¤; Quer-Out; Rati Salil D; Repak;
Reumol Diclo; Reumosan; Rodinac; Salicrem Forte; Silfox¤; Tomanil¤; Venzidiak; Vesalion; Viartril NF¤; Vimultisa; Virobron Gel; Virobron NF¤;
Volforte; Voltaren Colirio¤; Voltaren Migra¤; Voltaren; Xedenol; Xina¤;AUSTRALIA: Arthrotec; Clonac; Dencorub Anti-Inflammatory¤; Diclac¤;
Diclohexal¤; Dinac¤; Fenac; Imflac¤; Solaraze; Viclofen¤; Voltaren Ophtha; Voltaren; Voltfast;AUSTRIA: Agilomed¤; Algefit¤; Arthrotec;
Dedolor; Deflamat; Deflamm¤; DiclacHexal; Diclaxol¤; Diclo-B¤; Diclo-Vision; Diclobene; Diclomelan¤; Diclostad; Diclosyl¤; Difene¤; Dolo-
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Voltaren¤; Dolostrip¤; Dolpasse; Fenaren¤; Flector; Magluphen¤; Naclof¤; Rheumabene¤; Solaraze; Thermacare; Tratul; Voltadol; Voltaren;
Zymamed¤;BELGIUM: Arthrotec; Cataflam; Dicloabak; Diclofast¤; Diclofemed¤; Diclotop¤; Diclotopic; Docdiclofe¤; Flector; Kinespir; Motifene;
Polyflam¤; Voltapatch¤; Voltaren;BRAZIL: Artren; Augelit¤; Bel-Gel¤; Belfaren; Benevran; Biofenac; Biofladex; Cataflam; Cataflex¤;
Cataflexym; Catalgem¤; Cataren¤; Cinaflan¤; Cinatil¤; Clofaren¤; Clofen; Clofenak; Clofenid¤; Deltaflogin¤; Deltaren¤; Desinflex¤; Dflam;
Diclac; Diclo P; Dicloair; Diclof¤; Diclofen¤; Diclofenax¤; Dicloflogil¤; Diclogenom¤; Diclokalium¤; Diclonaco¤; Diclonatrium¤; Diclonax¤;
Diclonil¤; Diclosod¤; Diclosodico¤; Diclostir¤; Dicloton¤; Difenan¤; Dioxaflex¤; Dnaren; Dorflan¤; Dorgen¤; Doriflan; Dorpiren¤; Dryltac;
Fenaflan; Fenaren; Fenburil¤; Fisioren¤; Fladon¤; Flamalgen¤; Flamatrat; Flanakin¤; Flanaren¤; Flexamina¤; Flodin Duo; Flogan; Flogesic¤;
Flogiren¤; Flogonac¤; Flotac; Gezon¤; Globaren¤; Infladex; Infladoren¤; Inflamax; Inflamex¤; Inflaren¤; Kindaren¤; Lifaren¤; Luparen¤;
Maxilerg; Neocoflan; Neotaflan; Neotaren; Olfen¤; Optamax¤; Ortoflan¤; Phaster¤; Poltax; Probenxil; Prodofenaco¤; Profenac¤; Reumadil¤;
Reumaren¤; Reutaren¤; Reutrite¤; Sintofenac¤; Soden¤; Sodix; Somaflex; Still; Tekaflex¤; Tonaflan¤; Tricin¤; Vendrex; Volflanil¤; Voltaflan;
Voltaflex; Voltaren Colirio; Voltaren; Voltrix; Zotac;CANADA: Apo-Diclo; Arthrotec; Cambia; Diclotec¤; Novo-Difenac¤; Nu-Diclo¤; Pennsaid;
Pro-Diclo; Vofenal¤; Voltaren Ophtha; Voltaren;CHILE: 3A Ofteno¤; Amofen¤; Artren; Autdol; Cataflam; Deflamat; Diclac; Diclotaren; Dicogel;
Dignofenac¤; Dolodrops; Elitiran; Exflam¤; Flamesan; Flector; Flotac; Klafenac; Lertus; Merpal; Noxiflex¤; Oftic; Pevoran; Pirexyl; Piroflam; Pro
Lertus; Promerpal; Sipirac; Turbogesic; Voltaren; Zorvolex;CHINA: Aofen (澳芬); Apo-Diclo (奥贝); Arthrotec (奥斯克); Bi Si Fu (毕斯福); Chen
Jing (辰景); De Fu Ka (得富卡); Di Fu Xin (迪扶欣); Di Pu (迪普); Diclac (迪克乐克); Difene (戴芬); Difnal (迪弗纳); Digen (迪根); Fei Ya Ning (菲亚
宁); Fei Yan (非言)¤; Fen Di Ning (芬迪宁); Fen Na Ke (芬那克); Fendi (芬迪); Gede (格得); Ji Song (吉松); Jiu Ning (久宁); Kaflan (扶他捷); Kang Tai
(康泰); Lai Bi Xin (来比新); Li Shu (立舒); Lu Lin (路林); Luck (乐可); Luo Pu Jia (洛普佳); Novolten (诺福丁); Olfen (奥尔芬)¤; Pu Ta Ning (普他宁);
Rui Pei En (瑞培恩); Shi Xiang (仕象); Si Fu Xin (思孚欣); Tian Jun Li (天君利); Tian Xin Li De (天新利博); Tong Du Ding (同杜叮); Voltaren (扶他林);
Voren (非言); Xi Shu (昔舒); Xin Pu Fen (欣普芬); Yi Er Song (依尔松); Yi Ke (依柯); Yi Ke Lin (宜克林); Yi Lin (依林); Yingtaiqing (英太青); Zhi Qing
(至清);CZECH REPUBLIC: Almiral; Apo-Diclo; Arthrotec¤; Dicloabak; Diclofen¤; Dicloin; Dicloreum; Dicloziaja; Dicuno; DIKY; Dolmina;
Dorosan¤; Feloran¤; Flector; Inflamac¤; Inflamalgin; Monoflam¤; Myogit¤; Naclof¤; Naklofen¤; Olfen; Rewodina¤; Sophenoderm¤;
Uniclophen; Uno; Veral; Viklaren¤; Voltaren;DENMARK: Alterflex¤; Arthrotec; Diclodan; Diclogea¤; Diclon; Diclopax¤; Diclosup; Dicuno;
Difenet¤; Eeze; Fenacop¤; Fenacta¤; Flector; Instantin¤; Modifenac; Solaraze; Voltabak; Voltadol; Voltaren; Voltarol; Vostar¤;FINLAND:
Arthrotec; Dicloabak; Diclometin¤; Diclomex; Dicuno; Eeze; Flector¤; Motifene; Pennsaid¤; Solaraze; Trabona¤; Voltaren; Voltfast;FRANCE:
Antacalm; Artotec¤; Compralfene¤; Dicloced¤; Dispadol¤; Flector; Flectoreffigel; Flectortissugelep; Solaraze; Tendol; Tevalgiespray¤; Voldal¤;
VoltarenActigo; Voltarendolo¤; Voltarene; Voltarenophta; Voltarenophtabak; Voltarenplast; Voltarenspe; Xenid¤;GERMANY: Allvoran¤;
Arthotec; Arthrex Duo¤; Arthrex¤; Benfofen¤; Delphimix 1¤; Delphinac¤; Diclabeta¤; Diclac¤; Diclo-Attritin¤; Diclo-Divido¤; Diclo-Gel¤; Diclo-
OPT¤; Diclo-Puren¤; Diclo-saar¤; Diclo-Spondyril¤; Diclo-Tablinen¤; Diclo-Vision; Diclo; Dicloberl¤; Diclodoc¤; Diclofenbeta¤; Diclogrun¤;
Diclomerck¤; Diclophlogont¤; Diclorektal¤; Difen; Dignofenac¤; Dolgit-Diclo¤; dolobasan¤; DoloVisano Diclo¤; duravolten¤; Effekton¤;
Flector; Jenafenac¤; Jutafenac¤; Lexobene¤; Monoflam¤; Myogit¤; Optalidon Zahnschmerz mit Diclofenac¤; Rewodina¤; Rheumasan D¤;
Sandoz Schmerzgel¤; Sigafenac¤; Silino¤; Solacutan; Solaraze; Toryxil¤; Voltaren Ophtha; Voltaren;GREECE: Actisuny; Anthraxiton¤;
Arthrotec¤; Batafil; Cataflam¤; Clonac¤; Contralg¤; Counterflame¤; Declofon¤; Delimon; Denaclof; Dicloabak¤; DicloDuo Combi; Diclofast¤;
Dicloin; Diclojet¤; Diclophlogont¤; Dicloplast; Dicloral¤; Difend¤; Dinaclon¤; Evinopon; Eyeclof¤; Fenaraze; Fenoclof; Figrel¤; Flefarmin¤;
Inflaforte; Linobol¤; Miniflam; Optobet¤; Pain-Out; Pengon¤; Pennsaid; Pharmaxaid¤; Qpain; Relipain¤; Remius; Rheumavek¤; Ruvominox;
Sailib; Sfinac; Sooneral; Topalgon; Urigon; Vilacril¤; Vilonit¤; Voltadol; Voltaren; Vurdon; Zarpen; Ziliprol;HONG KONG: A-Fenac; Abitren¤;
Actrol; Aflamin¤; Almiral; Analpan; Apo-Diclo; Arclotaic; Arfine; Artharen; Arthrotec; Aston; BF-Ofene; Brudic¤; Canfol; Cataflam; Clofec;
Clofenac; Clofenex; Clofenol; Curinflam¤; DDL; Defnil; Depan; Diclo-Ache; Diclo-Denk¤; Diclo; Diclocain¤; Dicloced; Diclofen; Diclofon;
Diclogesic; Dicloplaster; Dicloran; Dicloren; Dicloset; Diclowal¤; Dicofen; DicoPad; Difen; Difena; Difenac; Difengesic; Difenol; Difisal; Diflam;
Dinac; Dinopan; Divon¤; Doroxan¤; Dynapar; Erdon; Eunac; Eurofenac; Fenac; Fenadium; Fip Tondonac; Flector; Flexy; Flogofenac¤; Formin;
Fungoling; Gasica; Grofenac¤; Houluoning; Inflanac; Itami; Jointaren; KD-Fen; Kojar-Diclofen; Lesflam; Lignopain; Lufenac; Milfaren; Nati-
Pain; Neo-Clofen; Neo-Taren; Neodol-K; Neurogesic; Novo-Difenac¤; Olfen; Osco Tondonac; Painoff; Panacon; Panaflex; Panamor;
Parafortan¤; Pengesic; Protafen; Pyrana Volta; Qualifenac; Reclofen; Remafen; Remethan; Ren; Rhemofenax; Rofenac; Rumacur; Ruvominox;
Sawto; Scantaren; Shoren; Sting; Synfenac; Taks; Tapain; Tondonac; Toraren; Turbogesic; U-Taren; Umeran; Uniren; Varitaren; Vartelon;
Vetin; Vickstaren; Viclofenac; Vigolin; Voldapen; Volna; Voltaren Ophtha¤; Voltaren; Voltex Kool; Volton; Volverac; Voren; Votalen; Votalin;
Votan; Vurdon; Weidaren; Xoease; Yugokin; Zolase; Zolterol; Zucon;HUNGARY: Algoplast; Cataflam; Diclac; Diclomel; Diclopram; Diflam;
Dixol; Doloflex; Flameril¤; Flector; Flectorin; Fortedol; Huma-Difenac¤; Olfen¤; Veral¤; Voltaren Ophta; Voltaren;INDIA: Aclomax; Adgel;
Adiflam; Agile-K; Agile; Alefen; Antiflam; Argesic; Ark; Armdic; Artilov; B-Nac; Beconac; Bestodek; Bidnac; Bionac; Bioran; Cadmax; Cannact;
Caredec; Clopar; Cofenac; Combinac; D-Nova; Dacron; Deeclo; Defcin; Delbitol; Delta-K; Demo; Dersy; Devona; Diclam; Diclasia; Diclo-DT;
Diclo-K; Dicloact; Dicloat; Diclobit; Diclodol; Diclodyne; Diclofam; Diclofast; Diclofen; Dicloflam; Dicloflame; Diclolab; Dicloma; Diclomax;
Diclomol; Diclomol; Diclomove; Diclonac; Diclonet; Diclonij; Diclonip; Diclonova; Dicloran; Diclostar; Diclotal; Diclovar; Diclowin; Diclozed;
Dicnac; Dicnacx; Dico; Dicol; Dicoliv; Dicos; Dicron; Dicven; Difenac; Difenic; Difin; Difisal; Diklofen; Dikonb; Dikpa; Dikul; Dilofen; Dilona;
Dion; Disoral; Divexx; Divon; DLF; Dofec; Doflex; Dolact; Dolocide K; Dolzy; DS-15; Dynapar; E-Nac; E-Par; Emflam; Emflam; Esgipyrin DS;
Exflam¤; Fegan; Fenac; Fenbest; Fendase; Fengel; Fenlodac¤; Fensaid; Fensaide; Fento; Fineact; Flamese; Flexigesic-K; Flexigesic; Gic;
Haloran; I-Gesic; Imflamol; Inac; Indofen; Intragesic; Jonac; Justin; K-Fenac¤; Knac; Lafen; Leemax; Lipcy; Lofen; Lofy; Lysoflam; Mifenac;
Mindol¤; Mishanac; Misonac; Mobiaid; Mobyle; Nac Gel; Nac; Naclo; Nal-M; Neodol; Nifdec; Noctel; Novofen; Novoflam; NSAID Eye; Nudiclo;
Nufenac; Nupatch; Odonac; Onafen; Ontac; Oronac; Osteoflam; Oxalgin-D; Oxalgin-SR; Oxalgin; Oxynal; Painkair; Panama; Parafortan;
Profenac; Reactine; Relaxyl; Solunac¤; Tromagesic; Tromax¤; Voveran;INDONESIA: Abdiflam¤; Aclonac; Alflam; Anuva; Araclof; Atranac;
Berifen¤; Bufaflam; Cataflam; Catanac; Deflamat; Dicloflam; Diclomec¤; Diflam; Divoltar; Eflagen; Elithris; Exaflam; Fenaren¤; Fenavel;
Flamar; Flamenac¤; Flamic; Flamigra; Flamsy; Flazen; Galtaren; Gratheos; Inflam; Kadiflam; Kaditic; Kaflam; Kamaflam; Klotaren; Laflanac;
Linac; Matsunaflam; Megatic; Merflam; Mirax; Nacoflar; Nadifen; Neurofenac; Nichoflam; Nilaren; Potaflam; Potazen¤; Proklaf; Prostanac¤;
Provoltar; Raost; Reclofen; Renadinac; Renvol¤; Scanaflam; Scantaren; Tirmaclo¤; Troflam; Valto; Volmatik; Voltadex; Voltaren Ophtha;
Voltaren; Volten; Voren; X-Flam; Xepathritis; Yariflam¤; Zegren; Zorvolex;IRELAND: Arthrotec; Cataflam; Diclac; Diclo¤; Diclomax¤; Diclomel¤;
Difene; Flector¤; Kyflam¤; Otriflu¤; Solaraze; Vologen¤; Voltarol Ophtha; Voltarol; Voltfast¤;ISRAEL: Abitren; Arthrotec; Betaren; Cataflam;
Demofenac¤; Dicloftil; Dicloplast; Dicloren; Diclovit; Olfen¤; Osteomine; Physicare Gel; Sunactic; Swiss Relief; Voltaren Ophtha;
Voltaren;ITALY: Akisflam; Algosenac; Artrofenac¤; Artrotec; Cataflam¤; Dealgic; Deflamat; Diclocular; Diclodol¤; Diclofan; Dicloftil; Dicloral;
Dicloreum; Diclotears; Diclovec; Diep Grat; Dolaut; Doroxan; Dropflam; Fastum Antidolorifico; Fenadol; Fender; Flector; Flogofenac;
Forgenac¤; Inforce; Itami; Leviogel; Lisiflen¤; Misofenac; Molfenac¤; Nadiclopht; Novapirina; Pennsaid; Ribex Flu¤; Solaraze; Topfans¤;
Traulen; Voltadol; Voltadvance; Voltaren; Voltfast; Zeroflog;JAPAN: Adefuronic; Anavan¤; Blesin¤; Bolabomin¤; Daispas¤; Fenacidon¤;
Irinatolon¤; Naboal; Sannax¤; Savismin; Thicataren¤; Voltaren;MALAYSIA: Almiral; Analpan; Apo-Diclo¤; Avonac; Cataflam; Clofec; Clofenac;
Dicloran; Difnal; Doroxan; Fenac¤; Fenadium¤; Inflanac¤; Lesflam¤; Neo-Pyrazon¤; Olfen; Panaflex Extra; Remafen; Remethan; Rhemofenax;
Rhewlin¤; Taks¤; Uniren; Vokam; Voltaren; Voren; Votan; Wari-Diclowal¤; Zolterol;MEXICO: 3A Ofteno; Algenac¤; Alsidexten¤; Ariflam¤;
Artrenac Pro; Artrenac; Artrene; Artrotec; Atalak; Calaffler; Catafast; Cataflam; Clo-Far; Clofenix; Clonodifen¤; Coral¤; Deflox; Dicfafena;
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Diclac; Diclofarin; Diclopisa; Dicloran; Diclosol¤; Dioxaflex; Diqfanol; Dirret; Docril; Dofen¤; Doflatem; Dolaren; Dolflam; Dolofenac¤; Doltarac;
Ehlifena¤; Evadol; Fenagel; Fenalgin; Fervex; Flamydol; Flamygel; Flankol; Flogoken; Flotac; Fortical; Fustaren¤; Galedol; Hipo Sport; Lertus;
Lifenac; Liroken I; Liroken; Lodyfen; Logesic¤; Lonatec¤; Lufac-Z; Mafena; Manacon¤; Merxil; Metracin¤; Musol; Nediclon; Neo-Dolaren;
Ormofen; Pharmaflam¤; Practiser¤; Precifenac; Selectofen; Solof¤; Still¤; Uni-Fenil¤; Vicmafen¤; Volfenac; Voltaren; X Ray;NETHERLANDS:
Areston; Arthrotec; Cataflam; Dicloabak; Eminocs; Itami¤; Misofenac¤; Naclof; Normulen¤; Otriflu¤; Voltaren Emulgel; Voltaren;NORWAY:
Arthrotec; Cataflam; Dicuno¤; Modifenac; Naclof¤; Otriflu¤; Solaraze; Voltaren Ophtha; Voltaren; Voltarol;NEW ZEALAND: Anfenax¤; Apo-
Diclo; Cataflam¤; Diclax¤; Diclohexal; Flameril¤; Voltaren Ophtha; Voltaren; Voltfast¤;PHILIPPINES: Acuflam; Artisin-S; Canefol; Catafen;
Cataflam; Cataflin; Clofenex; Clofenix¤; Clofil; Clonaren¤; Curafen; Dafenac; Diclogen; Diclon; Diclonac; Diclowal; Dicofen; Dicsod; Dictas;
Difenamin; Difenax; Diflapane; Diflosid; Dolfen; Doloflam; Dycon¤; Dyflaren¤; Dynapar; Eslofen¤; Fenaspec; Fendil; Flexgel; Get-Go-Plus;
Globanac; Klaxon; Lobafen; Lofenax; Maxi¤; Medclof; Mioclof; Neo-Pyrazon; Nepenthe¤; Parafortan; Rheuflam; Subsyde; Uniclonax¤; Vifenac;
Vodefen; Volfenn¤; Voltaren; Voren; Votan; Zobid¤; Zolterol;POLAND: Akis; Apo-Diclo¤; Arthrotec; Cataflam; Diclac; Dicloabak; Dicloberl;
Diclobion¤; DicloDuo Combi; DicloDuo; Dicloratio; Dicloreum; Diclotica; Dicloziaja; Dicuno; Difadol; Diklonat P¤; Dikloziaja¤; Diky; Felogel;
Glimbax; Itami; Majamil; Naclof; Naklofen; Olfen; Ratiogel¤; Rewodina¤; Solacutan; Veral; Viklaren; Voltaren; Voltenac¤; Vostar¤;PORTUGAL:
Arthrotec; Cataflam; Clofen¤; Dagesil; Dicipan; Dicloabak; Diclodent; Diclofar¤; Dicloftal¤; Diclogel; Diclospray; Diclotec¤; Diflac; Difnan¤;
Dofene¤; Dolacen; Dorcalor¤; Fenac; Fenil-V; Flameril; Flector; Frenalgil; Holactiv; Olfen; Otriflu¤; Painex; Pennsaid¤; Reumolide; Solaraze;
Voltadol¤; Voltaren; Wergyl; Zaflex;RUSSIAN FEDERATION: Almiral (Алмирал)¤; Apo-Diclo (Апо-дикло)¤; Arthrotec (Артротек)¤; Bioran
(Биоран)¤; Dialrapid (Диалрапид); Diclac (Диклак); Diclo-F (Дикло-Ф); Diclobene (Диклобене); Dicloberl (Диклоберл)¤; Diclogen (Диклоген);
Diclonat (Диклонат)¤; Dicloran (Диклоран); Diclovit (Дикловит); Dorosan (Доросан); Etyfenac (Этифенак)¤; Feloran (Фелоран)¤; Flameril
(Фламерил)¤; Flector (Флектор); Flotak (Флотак); Naclof (Наклоф)¤; Naklofen (Наклофен); Naklofen Duo (Наклофен Дуо); Neodol (Неодол)¤;
Ortofen (Ортофен); Ortofer (Ортофер); Ortoflex (Ортофлекс); Ortophen (Ортофен); Penseyd (Пенсейд); Rapten Duo (Раптен дуо)¤; Rapten
Rapid (Раптен Рапид); Rheumavek (Ревмавек)¤; Swissjet (Свиссджет); Tabuk-DI (Табук-ДИ); Uniclophen (Униклофен)¤; Voltaren
(Вольтарен);SOUTH AFRICA: Adco-Clofelam; Anfenax¤; Arcanafenac¤; Arthrotec; Arthru-Derm; Brovaflamp¤; Catafast; Cataflam; Cliniflam¤;
Dicloflam; Diclohexal; Difen; Difenac¤; Difenject; Dynak; Fenisun¤; Flexagen¤; Fortfen; Infla-Ban¤; K-Fenak; Naclof¤; Panamor; Pharmaflam¤;
Sodiclo¤; Veltex; Voltaren Ophtha; Voltaren;SINGAPORE: Almiral; Analpan; Apo-Diclo; Arthrotec¤; Biclopan¤; Cataflam; Clofec; Clofenac;
Diclo-Denk; Diclo; Dicloran; Diclowal¤; Difenac; Difnal; Fenac; Fenadium; Flector¤; Inac; Inflanac; Lesflam; Neo-Pyrazon¤; Neodol; Olfen;
Panaflex Extra; Panamax; Pritaren; Remafen; Remethan; Rhewlin; SP-Nadofen; Ultrafen; Uniren; Voltaren Ophtha; Voltaren; Voltfast; Voren;
Zolterol;SPAIN: Algistick; Artrotec; Di Retard; Dicloabak; Diclodolor; Diclokern; Dolo Nervobion¤; Dolo-Voltaren; Dolotren; Flectormed;
Liberalgium¤; Luase; Normulen¤; Ratioparch¤; Solaraze; Sulexon¤; Voltadol; Voltaren; Xibol¤;SWEDEN: Arthrotec; Dicuno; Eeze; Eezeneo;
Flector¤; Ignorin; Modifenac¤; Naclof¤; Solaraze; Voltaren Ophtha; Voltaren T; Voltaren;SWITZERLAND: Agofenac¤; Arthrotec; Athrofen¤;
Deflamat¤; Diclac; Diclo-Acino; diclo-basan¤; Diclo¤; Dicloabak; Dicloren; Diclosifar¤; DicloZ; Difen-Stulln; Ecofenac; Effigel; Fenisole¤;
Fenisun¤; Flam-X; Flector; Fortenac¤; Grofenac; Inflamac; Olfen; Primofenac; Relova¤; Rheufenac¤; Rhumalgan¤; Solacutan; Solaraze; Sport-
und Rheumagel; Tonopan; Traumasport¤; Vifenac; Voltaren Dolo; Voltaren Emulgel; Voltaren Ophta; Voltaren; Voltfast;THAILAND: Abitren¤;
Almiral¤; Ammi-Votara; Amminac; Antenac; Arclonac; Arthrotec¤; Cataflam; Catanac; Cencenac; Chinclona; Chinclonac; Clofec; Clofon;
Coolnac; Covonac; D-flam; Demac; Diclo; Diclofen; Diclogel; Diclogesic; Diclolan; Diclomol¤; Diclosian; Difaren; Difelene; Difen¤; Difenac;
Difengesic; Difeno; Difensic; Dinac; Dinefec; Dolonil; Dosanac; Fema; Fenac; Fenacaine; Fenacil; Fenagel; Flexy; Infenac; Inflamma; Inflanac;
Klyzen; Lesflam; Lofenac; Manfenac; Masaren; Medaren¤; Myfenax; Myonac; N-Zen; Naclof¤; Olfen¤; Ostaren; Pai-Noren; Painelief; Posnac¤;
Putaren¤; Remethan; Rhumanol; Rumatab¤; Sefnac; Silflam¤; Sinclonac; Subsyde; Taks¤; Tarjen; Tarjena; Uniren; V-Therlen; Vasalen¤;
Veenac; Ventarone; Vesconac; Volfen¤; Volfenac; Volnac; Volta; Voltanac; Voltaren; Voltex Kool; Voltfast; Volverac; Voren; Votamed;TURKEY:
Actinoma; Aklofen; Albaren; Arthrotec; Cataflam; Clodifen; Clofast; Deflamat; Diclactive; Diclofix; Dicloflam; Diclomec; Dicol; Dicorab; Difenak;
Difenject; Dikles; Diklo-S¤; Diklofar; Diklojik; Diklopain¤; Dikloron; Dikloron; Dikloteva¤; Dolorex; Dorado¤; Elfenor; Fevere; Flector¤; Inflased;
Kalidren; Katafast; Katafenac; Miyadren; Rabedic; Rapidus; Rediclon; Rodinac; Romatim; Volfenaks; Voltaflam; Voltaren Ophta;
Voltaren;UNITED ARAB EMIRATES: Clofen;UNITED KINGDOM: Acoflam¤; Adacium; Akis; Arthrotec; Defanac; Defenac; Dexomon; Dicloflex;
Diclomax; Diclotard¤; Diclovol; Diclozip; Digenac¤; Dyloject; Econac; Fenactol¤; Flamatak; Flamrase; Flexotard¤; Isclofen¤; Lofensaid¤;
Masidemen; Misofen; Mobigel¤; Motifene; Pennsaid; Rheumatac¤; Rhumalgan; Slofenac; Solaraze; Valenac¤; Volraman; Volsaid; Voltarol
Ophtha; Voltarol;UKRAINE: Almiral (Алмирал); Argett Duo (Аргетт Дуо); Catafast (Катафаст); Clodifen (Клодифен); Diclac (Диклак); Diclo-F
(Дикло-Ф); Diclobene (Диклобене)¤; Dicloberl (Диклоберл); Diclobru (Диклобрю)¤; Diclocain (Диклокаин); Diclopherol (Диклоферол)¤;
Diclosafe (Диклосейф); Diftal (Дифталь); Diklodev (Диклодев); Evinopon (Эвинопон); Megafen Plus (Мегафен Плюс)¤; Naclof (Наклоф);
Naklofen (Наклофен); Olfen (Олфен); Ortophen (Ортофен); Rapten (Раптен); Uniclofen (Униклофен); Voltaren (Вольтарен);UNITED STATES:
Arthrotec; Cambia; Cataflam¤; Dyloject¤; Flector; Klofensaid; Licart; Pennsaid; Solaraze¤; Voltaren; Voltaren; Zipsor; Zorvolex;VENEZUELA: 3A
Ofteno; Arthrotec; Artren; Campal; Cataflam; Clofen; Clofenac; Diagesic; Diclofen P; Diclosal; Diclostan¤; Difenac; Diklason; Diralon; Dival;
Doltren¤; Dynapar; Flogaren; Flotac; Klafenac; Ofaflan; Ofagesic; Oflafan; Oftic; Udox; Valdipot; Veralen; Viavox; Voltaren; Volten; Votaxil;
Preparations: Multi-Ingredient
The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.
ARGENTINA: Albesine Biotic¤; Algicler Flex; Algicler; Algio Nervomax Fuerte; Algio Nervomax¤; Amixen Plus; Anaflex Plus Rapida Accion Lib;
Befol Flex; Befol Plus; Belmalen; Bengue Sin Olor; Blokium B12; Blokium Cort; Blokium Flex; Blokium Gesic; Corteroid Gesic; Curinflam Plus;
Delta Tomanil B12¤; Desinflam Biotic¤; Diastone Flex; Diclofenac Flex¤; Diclogesic Forte; Diclogesic Plus B12; Diclogesic Relax; Diclolabsa B12;
Diclolabsa Gesic; Diclolabsa Relax; Diclomar Flex; Diclonex Flex; Diclonex R¤; Diklophar Flex; Dioxaflex B12; Dioxaflex Complex; Dioxaflex
Forte¤; Dioxaflex Gesic; Dioxaflex Plus; Dolo Nervobion 10000; Dolo Nervobion; Dolofenac Flex; Dolofenac Gesic; Dolofrix Plus; Dolvan Flex;
Doxtran B12¤; Doxtran Flex¤; Doxtran Gesic¤; Flaval Duo; Flaval; Flexiplen B12; Flexiplen Complex; Glifapen; Hyanac¤; Iglodine Flex;
Ingebrax¤; Lertus Biotic¤; Metaflex B12; Metaflex Gesic; Metaflex Plus; Meticil¤; Mio Aldoron NF¤; Nalgiflex Relax; Nervo Xedenol; Nodolerte;
Novo Klosidol; Oxa B12; Oxa Forte; Oxa Sport¤; Oxadisten; Oxafem¤; Oxagesic; Panclo B12; Pancloflex; Panclogesic; Prifec¤; Rodinac B12;
Rodinac Biotic; Rodinac Cort; Rodinac Flex; Rodinac Gesic; Silfox Flex¤; Tafirol Artro; Tobradiclo¤; Tobratlas; Tomanil Flex¤; Valuca Flex; Valuca
Plus; Venzidiak Flex; Vesalion B12; Vesalion Flex; Vesalion Gesic; Viartril Flex¤; Vimultisa Flex; Virobron B12 NF; Voltaren Flex¤; Voltaren
Forte¤; Xedenol B12; Xedenol Flex; Xedenol Gesic;AUSTRIA: Diclovit; Dolo-Neurobion¤; Neodolpasse; Neurofenac; Voltamicin¤;BELGIUM:
Ocubrax¤;BRAZIL: Algi-Butazolon¤; Algi-Tanderil; Alginac; Beserol; Cedrilax¤; Codaten; Diclofetamol¤; Dorpinol¤; Flexalgin; Infralax; Mioflex
A; Sedilax¤; Tandene; Tanderalgin; Tandriflan; Tandrilax; Tandrotamol; Torsilax; Trilax; Voltamicin¤;CHILE: Dolo-Neurobionta;CHINA: Meng
Luo Ying (蒙洛英); Muli (目力); Rui Li Tai (瑞立泰); Shu Er Fen (舒尔芬); Voltamicin (复美新); Wan Yan Ting (万严亭); Ya Bing (雅兵); Yu Luo Shu
(毓罗纾); Yu Wu Tai (玉五太);CZECH REPUBLIC: Neodolpasse; Voltamicin¤;FRANCE: Flector Tissugel Heparine; Voltamicine¤;GERMANY: B-
Voltaren¤; Combaren¤; Neuro-Effekton¤; Neurofenac¤; Voltaren Plus;GREECE: Tobrafen¤;HONG KONG: Lopper; Neurofenac¤; Neutalin;
14/7/2021 Lexicomp
Painstop; Parafortan¤; Parnac; Tendum; Vartelon-B; Vidaclofen-Plus¤;HUNGARY: Neodolpasse; Ocubrax¤; Voltamicin¤;INDIA: Acetonac;
Actimol-S; Actimol; Actizobid; Actizox-MR; Adgel-O; Adiflam Compound; Adlin; Adnac-MR; Adpep-D; Agile-MR; Agile-S; Agile; Agile; Aldase-D;
Aldidase-P; Aldidase; Alfapsin D; Amidase-D; Amidase-DP; Amizox; Anaida; Anaspas; Ara; Aram; Argesic Plus; Arifnac; Armdic MR; Armdic
Plus; Armdic SP; Artidin; Artifen-D; Artigesic-MR; Artilov; Aslera-D; Aslera-DP; Asolt-AT; Asolt; Aspa Plus; Atodase-D; Avifem-MR; Avifem;
Avisera Plus; Avisera-MR; Azet Plus; Balzox; Benzonac; Bestec; Betaspasm Forte; Bidnac; Binpain; Biodase-D; Bioflex; Bionac-Forte; Biopep-D;
Biozobid; Bral; Bufex-CD¤; Buta-M; Butacort-DP; Butaproxyvon; Butaproxyvon; C-MR; C-Nac; C-Serra-D; Cadiflam; Cadpo-D; Capsigyl-D;
Capsigyl-D; Capsitop; Cataspa; Ceflame-K; Ceflame; Cep-DP; Cep-MR; Chlorizok; Chymobel Plus; Chymosoz-D; Cipzen D; Cipzox; Clomet-P;
Clopar MR; Clopar Plus; Clopar-K; Coderan; Cofenac; Combigesic-DP; Combinac-MR; Combinac; Combinac; Combispas; Cuga Plus; Cuga;
Culin; Cure; Cuzen-DP; Cuzox-MR; CYS-D; Cytodec Forte; Cytodec; D-Kool; Dacpar-S; Dacpar; Dacpar; Dacron-Plus; Daze-D; Daze-DP; Dazina-
DP; Decizox; Deepas; Defenac-P; Delaxin-M; Delaxin; Delfina Plus; Delock-MR; Demo-MR; Demo-P; Demo-S; Demo-SP; Densera-D; Dentain;
Depain; Depas; Devona Plus; Devona-S; DFO; Diazox-MR; Diazox; Dic-OM; DIC; Dicin; Diciosis; Dicloact Plus; Dicloat Plus; Dicloat-CZ; Dicloat-
Gel; Diclobit; Diclofalm Forte; Diclofam Plus; Diclofast-P; Dicloflam MR; Dicloflam P; Dicloflam Plus; Dicloflam SP; Diclogen Plus; Diclogen
Plus; Diclogenta; Diclogesic Spas; Diclogesic; Diclohill-P; Diclolab Plus; Diclom-SP; Diclomax Power Gel; Diclomol; Diclomove-MR; Diclomove-
P; Diclonac-MR; Diclonac-P; Diclonet-Forte; Diclonij Spas; Diclonij-KMR; Diclonij-KP; Diclonij-Super; Diclonova MR; Diclonova P; Diclopace-CI;
Diclopep Plus; Diclopep; Dicloran-A; Dicloran-MR; Dicloran-MS; Dicloriz; Dicloriz; Diclosar-P; Diclosef; Diclosim; Diclospa; Diclosym; Diclotab;
Diclotal Forte; Diclotop; Diclovar-CZ; Diclovar-Plus; Diclowin Active; Diclowin Plus; Diclowin; Diclozed-Gel; Diclozed-Plus; Dicnac Gelino; Dicnac
MR; Dicnac Plus; Dicnac-P; Dicnacx-P; Dicnacx-S; Dicnacx-SP; Dicnap-MR; Dicnap; Dicnap; Dico P; Dicol-MR; Dicol-Plus; Dicol-S; Dicoliv Plus;
Dicoliv-MR; Dicoliv-S; Dicoliv; Dicron Plus; Dicron-C; Diculone; Dicven Plus; Dicyclozed; Diczone Plus; Diczone-MR; Difenac Plus; Difenac; Difin
Plus; Difin Plus; Difin-S; Difisal Plus; Difisal Relax; Diflac Plus; Dikpa; Dikul MR; Dikul P; Dikul SP; Dil SE; Dilofen-CZ; Dilofen-MR; Dilofen-P;
Dilona Plus; Dilona-SP; Dilophen-SP; Dinecol; Dion MR; Dion-P; Dion; Diopra; Dipal-F; Dipclo-MR; Diser; Divexx-MR; Divexx-P; Divexx; Divon
Plus; Divon-S; Divon; Divorel Plus; Dixer-S; Dixfree-SP; Dizox; Dodo-MR; Dodo; Dofec Plus; Dofec-S; Doflex Plus; Dol; Dolact; Dolact; Doloban;
Dolobid-M; Dolocide KP; Dolocide MR; Dolocide Plus; Dolofenac; Dolopar; Dolozox; Dolwin; Don-MR; Don; Dordase-D; Dordase-DP; DP Gesic
MR; DP Gesic; DP-Spas; Dpazox; Drab; DS-15; DSM; DSP; DTN; Dual Gesic Plus; Dual Gesic; Dublact; Dufex¤; Duoflam Gel; Duoflam Spy;
Duospan; Dynapar LD; Dynapar PPI; Dynapar; E-Diclo-Gel; E-Fen-CZ; E-Fen; Ebility; Edase-D; Elaxic; Elnim-D; Elwin-Plus; Emanzen-D;
Emanzen-DP; Emsulide-Fen; Enzoflam; Enzoflam; Enzovexx; Erase-D; Esgipyrin; Eudase-D; Eudase-DP; Everser-D; Felini; Fenac-P; Fenadec
MR; Fenadec Plus; Fenaplus-MR; Fenaplus-RX; Fenaplus; Fendic Plus; Fensaide-P; Fenzone Forte; Fenzoxe Forte; Filco-S; Flamar-DP¤; Flamar-
MX¤; Flamese-K; Flamese-KR; Flamese; Flanzen-D; Flanzen-DP; Flaser-D; Flexibel; Flexicam; Flexigesic-MR; Flexigesic-S; Flexigesic; Flexura-D;
Flozen Plus; Forgesic-MR; Forgesic-SP; Forjoint; Freedom Forte; Freedom; Fremov; Frenac Plus¤; Gelospi; Gic-SR; Ginac; Godic-S; Haloran
Plus; Healpil; Hidiclo Plus; Hidiclo; Hidiclodase; Hooky; Hydase-D; Ibugesic Plus-NF; Ibumax; IJM-Gel; Imflamol-C; Imflamol-ZX; Inac-P;
Inflahit; Inflakod; Inflaryl-AD; Inflazone; Insider; Intagesic-MR; Intagesic; Intagesic; Intase DF; Intragesic-MR; Intragesic; Intragesic; Jonac
Plus; Jusgo-MR; Jusgo; K-Trip Plus; Kineto-D; Kineto-DP; Kinser-DP; Klick; Kloser-D; KMR; Kurdase Plus; Kurdase-D; Kymovil Plus; L-Divon;
Labdic Relief; Labdic Relief; Larigox; Lebec-D; Lebec-MR; Lenex; Lenin-D; Linif; Lipcy-A; Lipcy-MR; Lobak; Lowdol; Lupisulide-D; Lupivon-D¤;
Lyser-D; Lyser-DP; Lysoflam; Lysoflam; Magadol-SP; Magadol; Mahadol; Mardase-K; Maxigesic-MR; Maxigesic; Maxoflam-D; Maxoflam-MR;
Maxoflam; Maxoflam; Maxrel; Medicreme-Strong; Medinac; Megadase-D; Metadol; Mezonac; Microdase-D; Microdase-DP; Minidolo;
Mobifen; Mobiflam; Mobigel; Mobinorm-S; Mobinorm; Mobisox¤; Mobiswift-D; Mobitone; Mobizox; Mofax; Mortrin; Mosvar; Movex-SP;
Muscodac; Muscodac; Muskel; Muskel; Mydic-MR; Mydic-S; Myolaxin-D; Myospaz Forte; N-Pain Relief; Nac Plus; Naclomol-MR; Naclomol-S;
Naclomol; Naclomol; Nacmol Plus; Nacpo; Nacpo; Nacser-D; Nacser; Nal-PM; Neulab-D; Neurophen-Compound; Neurophen; New Mezonac;
Nicip D; Niclofen-S; Niclofen; Niclopar-S; Nidi-Spas; Nifgel; Nimdase; Nimelide Fen; Nimucet-Fen; Nimulase-D; Nimvista-D; Nobel Spas; Nobel;
Noctel; Novalini; Novaspas; Novil; Novodex¤; Novogel; Novonac; Nugesia-SP; Nugesia; Numol-MR; Numol; Oligel; Omni; Omnigel; Onafen-
CZ; Onafen; Onafen; Onspot; Ontac Plus; Ontact Forte; Optase-D; Optase-DC; Optizen-D; Oronac Plus; Oronac; Orra-D; Orthocos; Orthocure;
Orthodac-MR; Orthodac; Orthodac; Orthoris; Osdip-MR; Osdip; Osteoflam-MR; Osteoflam; Ostizox; Osynec-K; Ouch; Oxalgin Nanogel;
Oxalgin-DP; Oxybuta¤; Oxynal-P; Oxypamol-D; Pacizox; Paclo-MR; Painkair-MR; Painkair; Pamagin Plus; Panama-D; Panama; Paracip Plus;
Paradic-C; Paradic-MR; Paradic; Parafortan; Paratel-DS; Parazobid; Parazox-D; Reactine Forte; Reactine Plus; Relaxyl Plus; Relaxyl; Spasmo-
Proxyvon Forte; Systaflam;INDONESIA: Diklovit; Dolofenac¤; Neumed; Neurofenac Plus;ITALY: Voltamicin¤;MALAYSIA: Voren Plus;MEXICO:
Ariflam Forte¤; Diclovith-B; Dioxaflex Duo; Dolaren; Dolnefort; Dolo-Neurobion; Dolo-Pangavit; Dolvifen; Dorixina-Flam; Duciclon; Duoflex;
Empatil; Lertus CD; Ortocol¤; Prestoflam; Tafirol AC; Trazinac; Tribedoce Compuesto; Uni-Dox; Voltaren Forte; Votripax;PHILIPPINES:
Neurofenac;POLAND: Dolonerv; Venozel;PORTUGAL: Latesil;RUSSIAN FEDERATION: Clodifen Neuro (Клодифен Нейро); Diclofenacol
(Диклофенакол); Diclogen Plus (Диклоген Плюс); Dicloran Denta (Диклоран Дента); Dicloran Plus (Диклоран Плюс); Dolaren (Доларен);
Hondrofen (Хондрофен); Neurodiclovit (Нейродикловит); Panoxen (Паноксен);SINGAPORE: Dinopen¤; Dosanac; Voltamicin¤; Voren
Plus;SPAIN: Algipatch; Coneurase¤; Ocubrax¤;SWITZERLAND: Flectoparin; Tobrafen¤; Voltamicin¤;THAILAND: Bufenac;TURKEY: AFTOjel;
Codefen; Cureflex; Diclomec Plus; Megaflex; Muscoflex Duo; Ocubrax; Voltonik;UKRAINE: Algozan (Альгозан); Bol-Ran (Бол-Ран); Diclofen-
Gel (Диклофен); Dicloran Plus (Диклоран Плюс); Diclosan (Диклосан); Dipren (Дипрен)¤; Dolar (Долар); Dolaren (Доларен)¤; Dolaren
(Доларен); Fanigan (Фаниган); Flamidase (Фламидез); Flamidase (Фламидез); Maxigesic (Максигезик); Movex Active (Мовекс Актив);
Neurodiclovit (Нейродикловит); Ocubrax (Окубракс)¤; Tilda (Тилда);VENEZUELA: Combaren; Painfort; Todenac; Trazinac;
Preparations: Pharmacopoeial
BP 2020: Diclofenac Gastro-resistant Tablets; Diclofenac Gel; Diclofenac Prolonged-release Capsules; Diclofenac Prolonged-release
Tablets;USP 43: Diclofenac Potassium for Oral Solution; Diclofenac Potassium Tablets; Diclofenac Sodium and Misoprostol Delayed-Release
Tablets; Diclofenac Sodium Delayed-release Tablets; Diclofenac Sodium Extended-Release Tablets; Diclofenac Sodium Topical Solution;
Therapeutic Use
Analgesics Anti-inflammatory Drugs and Antipyretics
Last Updated 6/29/21
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14/7/2021 Lexicomp
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Diclofenac Sodium: (Martindale: The Complete Drug Reference) Drug Nomenclature

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Diclofenac Sodium: (Martindale: The Complete Drug Reference) Drug Nomenclature

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14/7/2021 Lexicomp

Diclofenac Sodium (Martindale: The Complete Drug Reference)

United States Adopted Names

British Approved Names

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Adverse Effects, Treatment and Precautions

Last Updated 6/29/21

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